Search on: DNA GYRASE 
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Descriptor English:   DNA Gyrase 
Descriptor Spanish:   Girasa de ADN 
Descriptor Portuguese:   DNA Girase 
Synonyms English:   DNA Gyrase A Subunit
DNA Gyrase B Subunit  
Tree Number:   D08.811.399.403.741.149
D12.776.097.237
Definition English:   A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase. 
Entry Combination - descr/qualif English:   DNA Gyrase/antagonists & inhibitors use Topoisomerase II Inhibitors
 
History Note English:   2002; use DNA TOPOISOMERASE (ATP-HYDROLYZING) 1994-2001, use DNA GYRASE 1980-1993; for GYRA PROTEIN use DNA TOPOISOMERASE (ATP-HYDROLYZING) (NM) 1992-2001; GYRB PROTEIN use DNA TOPOISOMERASE (ATP-HYDROLYZING) (NM) 1991-2001 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   36089 
Unique Identifier:   D027081 

Occurrence in VHL:
 

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